The Ultimate Guide To Acetylcholine Supplements


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Trying to find the best acetylcholine supplements? Now that you have reached this website, I am sure you seek to uncover the best Acetylcholine supplement to use. For the sake of relevance, let’s first define what Acetylcholine is. ACh, as medics commonly refer to it, is a chief neurotransmitter in the brain responsible for memory, learning, though and synaptic plasticity.

As you may already know, having the right levels of acetylcholine in your body can help you improve your concentration, perception, verbal fluency, memory recall as well as some other cognitive functions. Did you know that having low levels of this important neurotransmitter could result in Alzheimer’s disease? I guess you did. Now lets take a closer look at Acetylcholine supplements!


Acetylcholine supplementsWhy do you need acetylcholine supplements?

It is clear that having proper levels of Acetylcholine goes a long way in helping you boost your brainpower via nootropic use. A nootropic is a drug, supplement or any other substance that improves cognitive functions. Research has it that up to 9 out of 10 US citizens do not obtain enough building blocks of ACh in their diets.

Oh, my friend, you could be among the ones having low levels of Acetylcholine in your brain. So, is it possible to raise these levels or you are condemned to suffer low brainpower with low cognitive abilities? This is where acetylcholine supplements come in. You will be surprised, but there is no 100% pure Acetylcholine supplement. However, you can find great supplements that can take to raise the levels of this vital neurotransmitter.

The Basic Types of Acetylcholine Supplements:

Supplements that can boost brain levels of acetylcholine come in three types that differ in their mechanism of actions. These include:

· Epitomized acetylcholine agonists: These supplements are epitomized with Piracetam and other racetams. They work by stimulating receptors in your brain to cause more acetylcholine to be released.

· Choline source and ACh intermediates: These supplements include Choline Bitartrate, Alpha GPC and CDP Choline that act as substrates to increase the production of acetylcholine in the brain. These nootropics are among the strongest acetylcholine supplements on the market.

· Acetylcholinesterase Inhibitors: Acetylcholinesterase is an enzyme in your brain that breaks down acetylcholine. Inhibiting its production increases the amount of the neurotransmitter present in the brain.

Acetylcholine inhibitors are perhaps the most common type of acetylcholine supplements currently in the market. Their unique mechanism of action makes them the most effective types at increasing the levels and activity of this nootropic.

Perhaps you have been using an acetylcholine agonist such as Piracetam to stimulate the release of acetylcholine, but you realize your body stores of this vital neurotransmitter are too low to meet your brain’s demands. You could be wondering how this could happen given the fact that ACh inhibitors are the most effective. Well, the problem could be in your diet. If you fail to take adequate amounts of acetylcholine precursors in your diet, then you may experience the unwanted effects such as headaches. The most effective solution my friend is to use choline supplement or ACh intermediary. These nootropics increase the levels of acetylcholine in the brain by supplying the raw material needed for the synthesis of the neurotransmitter.

The Five Most Common Choline and Acetylcholine Intermediaries

1. Phosphatidylcholine and Soy Lecithin

Phosphatidylcholine is a rich source of choline found in many foods including meat, dairy products, eggs, and fish. Lecithin, on the other hand, is available in soy products. Your body converts the choline in these products to acetylcholine. The problem is that choline is present in a very low concentration in these foods. That is why you need additional acetylcholine supplements in your diet.




2. Choline Bitartrate and Citrate

Most acetylcholine supplements in the market are present in the forms of Choline Bitartrate and Citrate. Many people like these supplements because they are affordable and effective in raising levels of acetylcholine. However, they do not have enough strength to provide you with nootropic effects on their own.




3. CDP-Choline or Citicoline

The ACh intermediary is more effective than the choline salts discussed above because they have the ability to cross the blood-brain barrier. For this reason, Citicoline can provide more acetylcholine in the brain compared to other Acetylcholine supplements. You might love it because it has very few side effects and therefore extremely safe.




4. Alpha GPC

Usually, the Alpha GPC is a powerful nootropic on its own, but you will find it as an acetylcholine supplement in the formulation along with racetams. If you take Alpha GPC as a supplement, it will break down into acetylcholine and a byproduct making a direct precursor. This acetylcholine supplement will help boost your memory, make it easier to learn new concepts and keep your brain healthy be relieving oxidative stress.



5. Centrophenoxine

Centrophenoxine is another choice of a very potent acetylcholine supplement that is effective. However, it is not very clear how it produces its nootropic effects. Evidence indicates that it raises the brain levels of ACh and has synergic effects with Aniracetam, Piracetam, and Oxiracetam.




What about Acetylcholinesterase Inhibitors?

Acetylcholinesterase is an enzyme that your body produces to break down and therefore eliminate excessive amounts of acetylcholine in your body. While this suppressive effect is necessary, at times, it has to be inhibited to increase the concentration of ACh and therefore boost memory and other cognitive functions of your brain.

Acetylcholinesterase inhibitor blocks the production of the enzyme and therefore makes it available to potentiate the effects of Acetylcholine. A perfect example of Acetylcholinesterase inhibitor is Huperzine A. This inhibitor is powerful, and it is currently the subject of research. Experts think that it could be the ultimate treatment for Alzheimer’s disease. Most medications used to treat Alzheimer’s have the same mechanism of inhibiting acetylcholinesterase.

So Then, What Is the Best Acetylcholine Supplement to Use?

We are back to our original question. But, we can answer it now, because we have learned the three different types of acetylcholine supplements currently available. It might surprise you, but no single type is comprehensive enough to provide you with the best results. We, therefore, recommend that you use all the three supplements together in a nootropic stack. Your personal goals should be determined the nootropic stack you use. Available options are too many, but good examples include Noopept, Citicoline, and Huperzine or Pramiracetam, Centrophenoxine and Huperzine.


I believe you already understand the importance of Acetylcholine, especially concerning memory and cognitive function. Having the right levels of the neurotransmitter in your brain can preserve, improve your memory and eliminate the risk of dreaded conditions such as dementia and Alzheimer’s. If you have the low brainpower and decide to use nootropic supplements, then you must have heard about acetylcholinesterase inhibitors (AChEIs).

What Is Acetylcholinesterase Inhibitor? 

This phrase may sound strange to you if you are not a medic but it means a class of substances that block the breakdown or catabolism of the neurotransmitter acetylcholine thereby influencing brain function. Acetylcholinesterase is the enzyme that breaks down of the neurotransmitter in the brain.

These substances work by inhibiting the functions of acetylcholinesterase around neurons to prevent it from destroying acetylcholine. By doing so, acetylcholine level increases leading to beneficial functions in higher brain functions.

Do you know what the good news is, my friend? Researchers believe harnessing the actions of acetylcholine inhibitors could open a breakthrough in the management neurodegenerative diseases such dementia, Alzheimer’s and other forms of cognitive impairment. Even if you are a relatively healthy individual, supplements based on acetylcholinesterase inhibitors could help augment your intelligence and brainpower.

Different Types of AChEIs

Experts recognize three different types of AChEIs depending on their mechanisms of action. These types include reversible AChEIs, irreversible AChEIs, and intermediate between the two. Reversible acetylcholinesterase inhibitors have actions that can be undone. Sometimes they are referred to as short-acting or short duration AChEIs, which used as memory enhancers and the treatments of Alzheimer’s and lucid dreams.

Irreversible types have actions that cannot be undone leading to irreversible effects. The type of AChEIs is used in the formulation of insecticides containing organophosphates. Clearly, the irreversible acetylcholinesterase inhibitors are not used in supplements. In fact, these inhibitors are used in lethal poisons, and venoms experts will always tell you to avoid.

Similarly, excessive inhibition of the enzyme can predispose you to serious side effects. However, smaller doses can help you develop better memory capacity, improve your brain’s plasticity and enhance your intellectual abilities. I guess everyone wants to be smart, brilliant and intelligent, don’t you?

Why Inhibit The Effect Of This Vital Enzyme?

Acetylcholinesterase plays an essential role in regulating brain functions.You way ask why anyone would want to inhibit its effect? The simple answer is that simple interference may be necessary to potentiate the beneficial implications of the neurotransmitter especially in mental performance and specifically memory.

The inhibitory effect of the enzyme increases the levels of acetylcholine neurotransmitter in your brain and at the same time increase the duration of its stimulatory effects. When neuron fires, a stronger action potential in the post-synaptic neuron (the neuron that receives the signal) potentiating the effects of ACh. Consider what happens when you turn up the volume of your audio machine. The sound will be louder. High levels of acetylcholine amplify, so to say, its effects on the parts of the brain responsible for cognitive functions.

Who Can Benefit From AChEIs? 

We all have good memories when we are younger but as we age, cognitive functions exemplified by memory start to decline progressively. In old age, higher brain functions reduce leading to conditions such as Alzheimer’s disease, dementia and other manifestations of impaired cognitive functions. If you or your loved one experience declining cognitive functions, then you are the right person for AChEIs. From what you have learned already, I believe you understand why.

Studies indicate that over 50 percent of people aged 85 years and above suffer from Alzheimer’s disease. Using acetylcholinesterase inhibitors has been shown to boost memory capacity in these seniors by compensating for naturally lower cholinergic activity. The fact is, memory loss and dementia are not curable but AChEIs offer a viable option that can improve the lives of people you love.

Recommended AChEIs Supplements 

The above discussion may not be helpful to you if I do not recommend to you any suitable Acetylcholinesterase inhibitor supplement to use. Two of the most popular AChEIs supplements you can buy are Huperzine A and Galantamine . Nevertheless, I would prefer Huperzine A to Galantamine. The former is more popular because it is safer, less potent, and therefore suitable for mental enhancement in normal individuals. Galantamine is stronger and therefore suitable for therapeutic management of cognitive impairment.

Huperzine A is a natural extract from the Chinese Huperzia A Serrata tree. You only need a small amount of Huperzia A to enjoy the benefits of acetylcholinesterase inhibition. Studies indicate that Huperzia A dosages as low as 200 micrograms per day can unlock your brainpower. While Huperzia A is sold as an independent memory supplement, to achieve the best you should combine it with other supplements in cognitive enhancement stack.

Good examples include Alpha Brain supplement by Onnit Lab. It contains high-quality Huperzia A. I would recommend you use a stack of several different supplements along with AChEIs to significantly improve your cognitive functions and help you retain and enjoy sharp memory as you age.



I bet you already know how important acetylcholine is when it comes to your higher brain functions including memory, learning, concentration and cognitive functions. Your cholinergic neurons synthesize acetylcholine from choline and acetyl-CoA. The choline your body uses comes from diet. Since choline is water soluble, your body cannot store it. Therefore, you need to replenish this important nutrient daily.

With the right choline dosage, you can maintain healthy levels needed by your brain to function optimally. Maintaining high doses of Alpha GPC Choline or CDP Choline can safely increase your brain levels of acetylcholine neurotransmitter. The result is improved memory formation and storage, easier learning of new things, clearer thoughts and faster recall. Who does not love these great cognitive abilities?

Choline has many positive effects including maintaining nerve transmission from your spinal cord to the intended targets such as the muscles, lungs, heart, and glands among others. Choline components also help to insulate your myelin sheaths, which cover and protect neurons and maintain efficient nervous system signaling. You can only enjoy these benefits by taking the right acetylcholine dosage.

What Is The Right Choline Dosage? 

According to the Federal Drug Administration (FDA), the recommended choline consumption for adult males is 550 mg minimum per day while females should take 425 mg per day. Expectant mothers should take 550 mg per day to promote proper neural development in their children. These are minimum levels necessary for a good brain health, but to unlock the full potential of your brainpower, you may need to supplement the levels of choline.

A great choline supplement is Choline Bitartrate. If you are using this supplement as part of your brain-boosting stack, then you can safely take up to 1 or 2 grams per day. Starting from such high doses may not be so safe; therefore, you need to start from lower Choline Bitartrate dosages of between 250 to 500 mg. You can then progress upwards slowly as you become familiar with the effects of the supplement.

For your own safety, you need to consult a health professional before taking any choline supplement. Taking this step is good because dosages are adjusted to suit your individual needs for you to enjoy optimal effects in cognitive enhancement. Diarrhea is a common side effect of Choline Bitartrate that you may experience if you start with a full dose of the supplement. Bacteria in the intestines heavily break down the Tartaric acid in this formulation leading to diarrhea. Another side effect is a fishy odor.

You can avoid these effects by splitting doses into several equal administrations all through the day and taking it with food to improve bioavailability. If Choline Bitartrate does not produce the positive nootropic effects on you, then you might consider changing to Choline Alpha GPC or Citicoline. The dosages of these choline supplements range from 300 mg to 1,200 mg per day. You will notice improvements in our cognitive abilities.

What to Do Incase Of Choline Overdose

While there have been several reports of choline overdose, no one has ever died from such overdose. In fact, not even serious side effects have been reported in association with the various choline supplements. Taking too much of choline powder has been associated with only mild side effects. Generally, these supplements have excellent safety records. You don’t have to worry about any tolerance issues.

When you are using very high dosages of choline (commonly referred to as Choline Mega Dose), you may experience some mild side effects such as increased swelling and salivation, slightly fishy odor, stomach upset and impaired appetite. Reducing choline dosage can help eliminate these side effects.


Over the centuries, changes in cultural habits, tastes and diets have starved our bodies from obtaining choline from our diet. The effect is choline deficiency, which leads to less brain plasticity and reduced ability to form new neural connections. The aftermath is reduced mental clarity, decreased memory, and reduced ability to argue or reason logically. In severe cases, such deficiency could lead to neurodegenerative diseases such as Alzheimer’s disease.

The exact mechanisms that lead to Alzheimer’s disease are not clear, but many experts blame it on nutrient shortages. That is why doctors think drugs that increase acetylcholine levels can reverse the effects of Alzheimer’s disease and dementia. There is a lot of research in this field. If proved, you and I could enjoy a good life with high brainpower simply by adding enough choline to our daily diets. Check now whether you have these 5 most common Acetylcholine deficiency symptoms!


How lovely can it be to have youthful memory and cognitive ability the whole of your life? I guess you Choline reach foodknow just how much. The good thing is that you can obtain good levels of choline from your daily diet if you only knew what foods to eat. The sources are simple and can be found in your local grocery stores. Rich sources include eggs, liver, salmon, wheat germ, beans cauliflower, peanut butter, skim milk, and broccoli.

The problem is most people will not consume nearly enough of these foods to obtain enough levels of choline. 3 ounces of the beef liver can deliver as much as 350 mg of choline. This means you will need to consume one or two servings of beef liver per day to meet the choline levels recommended by the FDA. I believe you cannot sever beef liver daily or other dietary sources. This leaves you with just one option – choline supplementation.

When looking for the best choline supplement to use, an important attribute to consider is bioavailability or the ability of the formulation to pass the blood-brain barrier to reach the cholinergic neurons. Some forms of choline supplements such Choline Citrate and Choline Bitartrate are potent, but they have a poor bioavailability. This limits their efficacy.

Just to give you a head start, a couple of excellent choline supplements with great bioavailability have worked around the problem by the use of Phosphatidylcholine as an intermediate. Phosphatidylcholine crosses the blood-brain barrier readily making the supplements fully bioavailable. Examples are CDP-Choline (Citicoline) and Alpha GCP. They work as end products and precursors of Phosphatidylcholine.

If you incorporate these choline supplements into your diet along with choline-rich foods, there is no doubt you will achieve healthy choline level as well as acetylcholine levels necessary for optimal cognitive performance.


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