Acetylcholine is a vital neurotransmitter responsible for transmitting signals between your brain cells. It controls a number of processes that are important in memory, cognition, learning and other aspects of higher brain functions. Low levels of the neurotransmitter can be increased by the right acetylcholine supplement. You need to know the symptoms of acetylcholine deficiency to prevent any irreversible effects including dementia and Alzheimer’s disease.

So, what are the common Acetylcholine deficiency symptoms?

Here are the most common acetylcholine deficiency symptoms to watch out for:

• Poor Short-Term Memory and Brain Fog

The neurons in your brain need acetylcholine to communicate with each other. The deficiency of this neurotransmitter will interfere such communication leading to difficulties in cognition, mental fatigue, and brain fog.

• Fatigue That Worsens With Exertion

Low-level fatigue is normal especially after doing some physically and mentally demanding job. However, if you are having fatigue all the time then you should start worrying about the levels of acetylcholine in your brain. Fatigue that worsens with exertion is a classic symptom of acetylcholine deficiency.

• Emotional Instability

It is normal to feel emotionally unstable at some point in life, especially following some traumatic experience. Nevertheless, if your emotions tend to take over in your daily life, then chances are high you are suffering from low acetylcholine levels. You will suffer the inability to cope with your emotions and your emotional state can be unpredictable.

• Fast Heart Rate

You are not supposed to be aware of your heart rate. When you have low acetylcholine levels in your brain, you will notice you heart beating faster than normal (tachycardia), because the parasympathetic nervous system is not able to slow your heart by the Vagus nerve. This cranial nerve uses acetylcholine to stimulate the sinoatrial node of your heart resulting in the slow heart rate.

• Gastroparesis/Constipation

The Vagus nerve referred to previously uses acetylcholine also to assist several aspects of digestion including stomach acid production, peristalsis (which is the movement of food and stool through the gastrointestinal tract), gall bladder function, the opening of the pyloric sphincter and supporting pancreatic function. Thus, acetylcholine deficiency can lead to many problems including chronic constipation/ gastroparesis with poor digestion and poor absorption of critical nutrients.

• Flushing

A classic symptom of acetylcholine deficiency is flushing (redness) of the face, neck as well as other parts of your body. Since many other conditions may cause flushing, it is important to consider this symptom alongside with other symptoms discussed previously.


These are the five most common symptoms of low acetylcholine levels. If you notice any or a combination of them, then you should see your doctor for a more formal diagnosis. The doctor may recommend some kind of therapeutic treatment or the right acetylcholine supplements to help increase the levels.

Here are some of the most popular acetylcholine supplements:


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